2a8a: Difference between revisions
New page: left|200px<br /> <applet load="2a8a" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a8a, resolution 2.00Å" /> '''Crystal structure o... |
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==About this Structure== | ==About this Structure== | ||
2A8A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]] with ZN and CD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2A8A OCA]]. | 2A8A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]] with ZN and CD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69]]. Structure known Active Sites: CDA, CDB and ZNB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2A8A OCA]]. | ||
==Reference== | ==Reference== | ||
Structural analysis of botulinum neurotoxin serotype F light chain: implications on substrate binding and inhibitor design., Agarwal R, Binz T, Swaminathan S, Biochemistry. 2005 Sep 6;44(35):11758-65. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16128577 16128577] | Structural analysis of botulinum neurotoxin serotype F light chain: implications on substrate binding and inhibitor design., Agarwal R, Binz T, Swaminathan S, Biochemistry. 2005 Sep 6;44(35):11758-65. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16128577 16128577] | ||
[[Category: Bontoxilysin]] | |||
[[Category: Clostridium botulinum]] | [[Category: Clostridium botulinum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: botulinum neurotoxin serotype f; catalytic domain; x-ray; zinc endopeptidase]] | [[Category: botulinum neurotoxin serotype f; catalytic domain; x-ray; zinc endopeptidase]] | ||
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Revision as of 12:07, 30 October 2007
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Crystal structure of Clostridium botulinum neurotoxin serotype F light chain
OverviewOverview
The seven serologically distinct Clostridium botulinum neurotoxins (BoNTs, A-G) are zinc endopeptidases which block the neurotransmitter release by, cleaving one of the three proteins of the soluble, N-ethylmaleimide-sensitive-factor attachment protein receptor complex, (SNARE complex) essential for the fusion of vesicles containing, neurotransmitters with target membranes. These metallopeptidases exhibit, unique specificity for the substrates and peptide bonds they cleave., Development of countermeasures and therapeutics for BoNTs is a priority, because of their extreme toxicity and potential misuse as biowarfare, agents. Though they share sequence homology and structural similarity, the, structural information on each one of them is required to understand the, mechanism of action of all ... [(full description)]
About this StructureAbout this Structure
2A8A is a [Single protein] structure of sequence from [Clostridium botulinum] with ZN and CD as [ligands]. Active as [Bontoxilysin], with EC number [3.4.24.69]. Structure known Active Sites: CDA, CDB and ZNB. Full crystallographic information is available from [OCA].
ReferenceReference
Structural analysis of botulinum neurotoxin serotype F light chain: implications on substrate binding and inhibitor design., Agarwal R, Binz T, Swaminathan S, Biochemistry. 2005 Sep 6;44(35):11758-65. PMID:16128577
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