5o3a: Difference between revisions

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'''Unreleased structure'''


The entry 5o3a is ON HOLD
==Human Brd2(BD2) mutant in complex with ET==
 
<StructureSection load='5o3a' size='340' side='right' caption='[[5o3a]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Chan, K.-H., Runcie, A.C., Ciulli, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5o3a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O3A FirstGlance]. <br>
Description: Human Brd2(BD2) mutant in complex with ET
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31P:METHYL+(2R)-2-[(4S)-6-(4-CHLOROPHENYL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]BUTANOATE'>31P</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o3a OCA], [http://pdbe.org/5o3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o3a RCSB], [http://www.ebi.ac.uk/pdbsum/5o3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o3a ProSAT]</span></td></tr>
[[Category: Chan, K.-H]]
</table>
[[Category: Runcie, A.C]]
== Function ==
[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chan, K H]]
[[Category: Ciulli, A]]
[[Category: Ciulli, A]]
[[Category: Runcie, A C]]
[[Category: Transcription]]

Revision as of 09:24, 15 February 2018

Human Brd2(BD2) mutant in complex with ETHuman Brd2(BD2) mutant in complex with ET

Structural highlights

5o3a is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.[1]

References

  1. ↑ LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018

5o3a, resolution 2.40Å

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