2dw1: Difference between revisions

Revision as of 01:29, 4 May 2008

Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal)

OverviewOverview

Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.

About this StructureAbout this Structure

2DW1 is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:17485084 Page seeded by OCA on Sun May 4 01:29:55 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2dw1.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2dw1 |SIZE=350|CAPTION= <scene name='initialview01'>2dw1</scene>, resolution 2.5&Aring;
+The line below this paragraph, containing "STRUCTURE_2dw1", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GM6:3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE'>GM6</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2dw1|  PDB=2dw1  |  SCENE=  }}
-|RELATEDENTRY=[[2dw0|2DW0]], [[2dw2|2DW2]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dw1 OCA], [http://www.ebi.ac.uk/pdbsum/2dw1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dw1 RCSB]</span>
-}}
 '''Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal)'''
@@ Line 28: / Line 25: @@
 [[Category: Igarashi, T.]]
 [[Category: Takeda, S.]]
-[[Category: apoptotic toxin]]
+[[Category: Apoptotic toxin]]
-[[Category: metalloproteinase]]
+[[Category: Metalloproteinase]]
-[[Category: svmp]]
+[[Category: Svmp]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 01:29:55 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:40:20 2008''