6byn: Difference between revisions
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==Crystal structure of WDR5-Mb(S4) monobody complex== | |||
<StructureSection load='6byn' size='340' side='right' caption='[[6byn]], [[Resolution|resolution]] 2.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6byn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BYN FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6byn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6byn OCA], [http://pdbe.org/6byn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6byn RCSB], [http://www.ebi.ac.uk/pdbsum/6byn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6byn ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gupta, A]] | |||
[[Category: Koide, S]] | |||
[[Category: Beta-propeller]] | |||
[[Category: Fibronectin]] | |||
[[Category: Inhibitor]] | |||
[[Category: Mll1]] | |||
[[Category: Transcription]] | |||