6fg7: Difference between revisions

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'''Unreleased structure'''


The entry 6fg7 is ON HOLD
==Crystal structure of the BIR2 ectodomain from Arabidopsis thaliana.==
 
<StructureSection load='6fg7' size='340' side='right' caption='[[6fg7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors: Hothorn, M., Hohmann, U.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6fg7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FG7 FirstGlance]. <br>
Description: Crystal structure of the BIR2 ectodomain from Arabidopsis thaliana.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fg7 OCA], [http://pdbe.org/6fg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6fg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fg7 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BIR2_ARATH BIR2_ARATH]] Pseudokinases lacking protein kinase activity and unable to bind ATP-analogs (PubMed:24556575). Negative regulator of pathogen-associated molecular patterns- (PAMP-) triggered immunity by limiting BAK1-receptor complex formation in the absence of ligands (PubMed:24388849).<ref>PMID:24388849</ref> <ref>PMID:24556575</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Hohmann, U]]
[[Category: Hohmann, U]]
[[Category: Hothorn, M]]
[[Category: Hothorn, M]]
[[Category: Ectodomain]]
[[Category: Leucine rich repeat receptor]]
[[Category: Membrane receptor]]
[[Category: Protein binding]]
[[Category: Pseudokinase]]

Revision as of 21:32, 24 January 2018

Crystal structure of the BIR2 ectodomain from Arabidopsis thaliana.Crystal structure of the BIR2 ectodomain from Arabidopsis thaliana.

Structural highlights

6fg7 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BIR2_ARATH] Pseudokinases lacking protein kinase activity and unable to bind ATP-analogs (PubMed:24556575). Negative regulator of pathogen-associated molecular patterns- (PAMP-) triggered immunity by limiting BAK1-receptor complex formation in the absence of ligands (PubMed:24388849).[1] [2]

References

  1. ↑ Halter T, Imkampe J, Mazzotta S, Wierzba M, Postel S, Bucherl C, Kiefer C, Stahl M, Chinchilla D, Wang X, Nurnberger T, Zipfel C, Clouse S, Borst JW, Boeren S, de Vries SC, Tax F, Kemmerling B. The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity. Curr Biol. 2014 Jan 20;24(2):134-43. doi: 10.1016/j.cub.2013.11.047. Epub 2014, Jan 2. PMID:24388849 doi:http://dx.doi.org/10.1016/j.cub.2013.11.047
  2. ↑ Blaum BS, Mazzotta S, Noldeke ER, Halter T, Madlung J, Kemmerling B, Stehle T. Structure of the pseudokinase domain of BIR2, a regulator of BAK1-mediated immune signaling in Arabidopsis. J Struct Biol. 2014 Apr;186(1):112-21. doi: 10.1016/j.jsb.2014.02.005. Epub 2014 , Feb 17. PMID:24556575 doi:http://dx.doi.org/10.1016/j.jsb.2014.02.005

6fg7, resolution 1.90Å

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