2d1o: Difference between revisions

Revision as of 23:31, 3 May 2008

Stromelysin-1 (MMP-3) complexed to a hydroxamic acid inhibitor

OverviewOverview

Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453 have been solved at 2.01 and 2.37A resolutions, respectively. The results revealed that the binding modes for this inhibitor to MMP-3 and -13 were quite similar. However, subtle comparative differences were observed at the bottom of S1' pockets, which were occupied with the guanidinomethyl moiety of the inhibitor. A remarkable feature of the inhibitor was the deep penetration of its long aliphatic chain into the S1' pocket and exposure of the guanidinomethyl moiety to the solvent.

About this StructureAbout this Structure

2D1O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453., Kohno T, Hochigai H, Yamashita E, Tsukihara T, Kanaoka M, Biochem Biophys Res Commun. 2006 May 26;344(1):315-22. Epub 2006 Mar 27. PMID:16603129 Page seeded by OCA on Sat May 3 23:31:40 2008

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OCA

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 [[Image:2d1o.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2d1o |SIZE=350|CAPTION= <scene name='initialview01'>2d1o</scene>, resolution 2.02&Aring;
+The line below this paragraph, containing "STRUCTURE_2d1o", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FA4:SM-25453'>FA4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2d1o|  PDB=2d1o  |  SCENE=  }}
-|RELATEDENTRY=[[2d1n|2D1N]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d1o OCA], [http://www.ebi.ac.uk/pdbsum/2d1o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2d1o RCSB]</span>
-}}
 '''Stromelysin-1 (MMP-3) complexed to a hydroxamic acid inhibitor'''
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 [[Category: Tsukihara, T.]]
 [[Category: Yamashita, E.]]
-[[Category: hydorolase metalloprotease]]
+[[Category: Hydorolase metalloprotease]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:31:40 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:29:11 2008''