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==Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 4-chloro-6-methylpyrimidin-2-amine== | |||
<StructureSection load='6bj7' size='340' side='right' caption='[[6bj7]], [[Resolution|resolution]] 1.56Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bj7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BJ7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DU7:4-chloro-6-methylpyrimidin-2-amine'>DU7</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | ||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cxq|5cxq]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bj7 OCA], [http://pdbe.org/6bj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bj7 RCSB], [http://www.ebi.ac.uk/pdbsum/6bj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bj7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/A0A0U3AGT1_SCHMA A0A0U3AGT1_SCHMA]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.[PIRNR:PIRNR000477] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Purine-nucleoside phosphorylase]] | |||
[[Category: Barbosa, J A.R G]] | |||
[[Category: Bird, L]] | |||
[[Category: Collins, P]] | [[Category: Collins, P]] | ||
[[Category: | [[Category: Delft, F V]] | ||
[[Category: Faheem, M]] | [[Category: Faheem, M]] | ||
[[Category: | [[Category: Neto, J B]] | ||
[[Category: | [[Category: Pearce, N M]] | ||
[[Category: Valadares, N | [[Category: Pereira, H M]] | ||
[[Category: Valadares, N F]] | |||
[[Category: Purine nucleoside phosphorylase]] | |||
[[Category: Transferase]] | |||
Revision as of 15:12, 7 November 2018
Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 4-chloro-6-methylpyrimidin-2-amineCrystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 4-chloro-6-methylpyrimidin-2-amine
Structural highlights
Function[A0A0U3AGT1_SCHMA] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.[PIRNR:PIRNR000477] |
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