5yvc: Difference between revisions

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-'''Unreleased structure'''
-The entry 5yvc is ON HOLD  until Paper Publication
+==A kinase-inhibitor complex==
+<StructureSection load='5yvc' size='340' side='right' caption='[[5yvc]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5yvc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YVC FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SU6:3-{2,4-DIMETHYL-5-[(Z)-(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-1H-PYRROL-3-YL}PROPANOIC+ACID'>SU6</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvc OCA], [http://pdbe.org/5yvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yvc RCSB], [http://www.ebi.ac.uk/pdbsum/5yvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN]] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Calcium/calmodulin-dependent protein kinase]]
+[[Category: Handa, N]]
+[[Category: Niwa, H]]
+[[Category: Yokoyama, S]]
+[[Category: Atp-binding]]
+[[Category: Calcium/calmodulin-dependent protein kinase kinase 2]]
+[[Category: Camkk2]]
+[[Category: Kinase]]
+[[Category: Protein-inhibitor complex]]
+[[Category: Serine/threonine-protein kinase]]
+[[Category: Transferase]]