Liver X receptor: Difference between revisions
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<StructureSection load='5kya' size='340' side='right' caption='Human liver X | <StructureSection load='5kya' size='340' side='right' caption='Human liver X receptor β ligand binding domain (grey) complex with retinoic X receptor β (green) and modulator (PDB code [[5kya]])' scene=''> | ||
== Function == | == Function == | ||
'''Liver X | '''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>. LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status. | ||
== Disease == | == Disease == | ||
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LXR modulator binds to the LXR in the LXR/retinoic X receptor β heterodimer in a hydrophobic pocket<ref>PMID:27599745</ref>. | LXR modulator binds to the LXR in the LXR/retinoic X receptor β heterodimer in a hydrophobic pocket<ref>PMID:27599745</ref>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of liver X | == 3D Structures of liver X receptor == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||