5ybv: Difference between revisions

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 ==The structure of the KANK2 ankyrin domain with the KIF21A peptide==
-<StructureSection load='5ybv' size='340' side='right' caption='[[5ybv]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
+<StructureSection load='5ybv' size='340' side='right'caption='[[5ybv]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5ybv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YBV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YBV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5ybv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YBV FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KANK2, ANKRD25, KIAA1518, MXRA3, SIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ybv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ybv OCA], [http://pdbe.org/5ybv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ybv RCSB], [http://www.ebi.ac.uk/pdbsum/5ybv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ybv ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ybv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ybv OCA], [https://pdbe.org/5ybv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ybv RCSB], [https://www.ebi.ac.uk/pdbsum/5ybv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ybv ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN]] Congenital fibrosis of extraocular muscles. The disease is caused by mutations affecting the gene represented in this entry.
 == Function ==
-[[http://www.uniprot.org/uniprot/KANK2_HUMAN KANK2_HUMAN]] Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.<ref>PMID:17476305</ref> <ref>PMID:22371500</ref>  [[http://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN]] Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).
+[https://www.uniprot.org/uniprot/KANK2_HUMAN KANK2_HUMAN] Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.<ref>PMID:17476305</ref> <ref>PMID:22371500</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 19: @@
 </div>
 <div class="pdbe-citations 5ybv" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Ankyrin repeat domain-containing protein|Ankyrin repeat domain-containing protein]]
+*[[Ankyrin repeat domain-containing protein 3D structures|Ankyrin repeat domain-containing protein 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Guo, Q]]
+[[Category: Large Structures]]
-[[Category: Liao, S]]
+[[Category: Guo Q]]
-[[Category: Min, J]]
+[[Category: Liao S]]
-[[Category: Structural genomic]]
+[[Category: Min J]]
-[[Category: Xu, C]]
+[[Category: Xu C]]
-[[Category: Cell adhesion]]