6bt5: Difference between revisions

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'''Unreleased structure'''


The entry 6bt5 is ON HOLD
==Human mGlu8 Receptor complexed with L-AP4==
 
<StructureSection load='6bt5' size='340' side='right' caption='[[6bt5]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
Authors: Schkeryantz, J.M., Chen, Q., Ho, J.D., Atwell, S., Zhang, A., Vargas, M.C., Wang, J., Monn, J.A., Hao, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6bt5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BT5 FirstGlance]. <br>
Description: Human mGlu8 Receptor complexed with L-AP4
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E7P:(2S)-2-amino-4-phosphonobutanoic+acid'>E7P</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bt5 OCA], [http://pdbe.org/6bt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bt5 RCSB], [http://www.ebi.ac.uk/pdbsum/6bt5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bt5 ProSAT]</span></td></tr>
[[Category: Hao, J]]
</table>
[[Category: Monn, J.A]]
== Function ==
[[Category: Vargas, M.C]]
[[http://www.uniprot.org/uniprot/GRM8_HUMAN GRM8_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:9473604</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Atwell, S]]
[[Category: Atwell, S]]
[[Category: Chen, Q]]
[[Category: Chen, Q]]
[[Category: Schkeryantz, J.M]]
[[Category: Hao, J]]
[[Category: Ho, J.D]]
[[Category: Ho, J D]]
[[Category: Monn, J A]]
[[Category: Schkeryantz, J M]]
[[Category: Vargas, M C]]
[[Category: Wang, J]]
[[Category: Wang, J]]
[[Category: Zhang, A]]
[[Category: Zhang, A]]
[[Category: Gene id: 2918]]
[[Category: Grm8]]
[[Category: L-ap4]]
[[Category: Mglur8]]
[[Category: Signaling protein]]

Revision as of 09:20, 7 February 2018

Human mGlu8 Receptor complexed with L-AP4Human mGlu8 Receptor complexed with L-AP4

Structural highlights

6bt5 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GRM8_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.[1]

References

  1. ↑ Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR Jr, Johnson BG, Schoepp DD, Belagaje RM. Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97. PMID:9473604

6bt5, resolution 2.92Å

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OCA
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