Ectonucleotide pyrophosphatase/phosphodiesterase: Difference between revisions
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<StructureSection load=' | <StructureSection load='4gtw' size='340' side='right' caption='Mouse ENPP1 complex with AMP and Zn+2 ions (grey) (PDB code [[4gtw]])' scene=''> | ||
== Function == | == Function == | ||
'''Ectonucleotide pyrophosphatase/phosphodiesterase''' family of proteins mediates purinergic signaling by degrading extracellular nucleotides and also participate in phospholipid metabolism<ref>PMID:28898552</ref><br /> | '''Ectonucleotide pyrophosphatase/phosphodiesterase''' family of proteins mediates purinergic signaling by degrading extracellular nucleotides and also participate in phospholipid metabolism<ref>PMID:28898552</ref><br /> | ||
*'''Ectonucleotide pyrophosphatase/phosphodiesterase 1''' (ENPP1) converts extracellular nucleotides into inorganic pyrophosphate<ref>PMID:23041369</ref>. It regulates osteoblast differentiation<ref>PMID:21930712</ref><br /> | |||
*'''Ectonucleotide pyrophosphatase/phosphodiesterase 1''' (ENPP1) converts extracellular nucleotides into inorganic pyrophosphate<ref>PMID:23041369</ref>. It regulates osteoblast differentiation<ref>PMID:21930712</ref><br /> | |||
*'''Ectonucleotide pyrophosphatase/phosphodiesterase 2''' or '''autotoxin''' (ENPP2) hydrolyzes lysophospholipids<ref>PMID:23041369</ref><br />. | *'''Ectonucleotide pyrophosphatase/phosphodiesterase 2''' or '''autotoxin''' (ENPP2) hydrolyzes lysophospholipids<ref>PMID:23041369</ref><br />. | ||
*'''Ectonucleotide pyrophosphatase/phosphodiesterase 4''' or (ENPP4) is an extracellular membrane protein which hydrolyzes adenine dinucleotide Ap3A thus causing platelet aggregation<ref>PMID:24338010</ref><br /> | *'''Ectonucleotide pyrophosphatase/phosphodiesterase 4''' or (ENPP4) is an extracellular membrane protein which hydrolyzes adenine dinucleotide Ap3A thus causing platelet aggregation<ref>PMID:24338010</ref><br /> | ||
*'''Ectonucleotide pyrophosphatase/phosphodiesterase 6''' (ENPP6) hydrolyzes choline-containing compounds like lysophosphatidylcholine<ref>PMID:23161088</ref><br /> | *'''Ectonucleotide pyrophosphatase/phosphodiesterase 6''' (ENPP6) hydrolyzes choline-containing compounds like lysophosphatidylcholine<ref>PMID:23161088</ref><br /> | ||
*'''Ectonucleotide pyrophosphatase/phosphodiesterase 7''' or '''alkaline sphingomyelinase''' (ENPP7) converts sphingomyelin into ceramide and phosphocholine<ref>PMID:28292932</ref><br /> | *'''Ectonucleotide pyrophosphatase/phosphodiesterase 7''' or '''alkaline sphingomyelinase''' (ENPP7) converts sphingomyelin into ceramide and phosphocholine<ref>PMID:28292932</ref><br /> | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
The active site of ENPP1 contains two functionally significant Zn+2 ions and the reaction product AMP<ref>PMID:23027977</ref>. | |||
</StructureSection> | </StructureSection> | ||