Unusual sequence numbering: Difference between revisions
Eric Martz (talk | contribs) |
Eric Martz (talk | contribs) |
||
| Line 49: | Line 49: | ||
Rarely, sequence numbers do not increase monotonically from N to C terminus. An example<ref>Thanks to Rachel Kramer Green of [[RCSB]] for this example.</ref> is [http://firstglance.jmol.org/fg.htm?mol=4zwj 4zwj] ([[4zwj]]). In this chimeric protein, chain A is numbered 1002-1161 continuing 1-326 continuing 2012-2361. That is, there are sudden jumps in numbering of consecutive amino acids: 1161 to 1, and 326 to 2012. At right is an excerpt from the ATOM records of the [[PDB file]] for 4zwj chain A. | Rarely, sequence numbers do not increase monotonically from N to C terminus. An example<ref>Thanks to Rachel Kramer Green of [[RCSB]] for this example.</ref> is [http://firstglance.jmol.org/fg.htm?mol=4zwj 4zwj] ([[4zwj]]). In this chimeric protein, chain A is numbered 1002-1161 continuing 1-326 continuing 2012-2361. That is, there are sudden jumps in numbering of consecutive amino acids: 1161 to 1, and 326 to 2012. At right is an excerpt from the ATOM records of the [[PDB file]] for 4zwj chain A. | ||
<center> | <center> | ||
<table width= | <table width=350><tr><td>[[Image:Not-monotonic-3sn6.png]]</td></tr><tr><td>3sn6: Eight amino acids displayed with sequence numbers in FirstGlance in Jmol.<ref name="how2">Display 1igy in FirstGlance in Jmol. Click ''Find'' and enter ''chain=B and 81-83''. Click ''Isolate'' and check ''Atoms with Halos''. Zoom in. In the left center after "Halos around:" click ''Change'', and then ''Clear Halos''. Check ''Sequence numbers'' (near the bottom of the upper left panel).</ref> Residue 1161 is peptide-bonded N-terminal to residue 1. Residue 2 is disulfide-bonded to residue 282.</td></tr></table> | ||
</center> | </center> | ||