Unusual sequence numbering: Difference between revisions
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[[Image:Sequence-not-monotonic-4zwj.png|frame|Excerpt from PDB file 4zwj showing non-monotonic sequence numbering in chain A.]] | [[Image:Sequence-not-monotonic-4zwj.png|frame|Excerpt from PDB file 4zwj showing non-monotonic sequence numbering in chain A.]] | ||
Rarely, sequence numbers do not increase monotonically from N to C terminus. An example<ref>Thanks to Rachel Kramer Green of [[RCSB]] for this example.</ref> is [http://firstglance.jmol.org/fg.htm?mol=4zwj 4zwj] ([[4zwj]]). In this chimeric protein, chain A is numbered 1002-1161 continuing 1-326 continuing 2012-2361. That is, there are sudden jumps in numbering of consecutive amino acids: 1161 to 1, and 326 to 2012. At right is an excerpt from the ATOM records of the [[PDB file]] for 4zwj chain A. | Rarely, sequence numbers do not increase monotonically from N to C terminus. An example<ref>Thanks to Rachel Kramer Green of [[RCSB]] for this example.</ref> is [http://firstglance.jmol.org/fg.htm?mol=4zwj 4zwj] ([[4zwj]]). In this chimeric protein, chain A is numbered 1002-1161 continuing 1-326 continuing 2012-2361. That is, there are sudden jumps in numbering of consecutive amino acids: 1161 to 1, and 326 to 2012. At right is an excerpt from the ATOM records of the [[PDB file]] for 4zwj chain A. | ||
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<table width=200><tr><td>[[Image:Not-monotonic-3sn6.png|200px|center]]</td></tr><tr><td>3sn6: Eight amino acids displayed with sequence numbers in FirstGlance in Jmol.<ref name="how2"></ref></td></tr></table> | |||
</center> | |||
Another example is the RNA chain R in [http://firstglance.jmol.org/fg.htm?mol=3sn6 3sn6] ([[3sn6]]). It is numbered 1002-1164 continuing 30-365. However the model lacks bonds between 1164 and 30 because amino acids 1161-1164 are missing due to crystallographic disorder. | Another example is the RNA chain R in [http://firstglance.jmol.org/fg.htm?mol=3sn6 3sn6] ([[3sn6]]). It is numbered 1002-1164 continuing 30-365. However the model lacks bonds between 1164 and 30 because amino acids 1161-1164 are missing due to crystallographic disorder. | ||