6f59: Difference between revisions

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-'''Unreleased structure'''
-The entry 6f59 is ON HOLD
+==Crystal structure of human Brachyury (T) G177D variant in complex with DNA==
+<StructureSection load='6f59' size='340' side='right' caption='[[6f59]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-Authors: Newman, J.A., Gavard, A.E., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6f59]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F59 FirstGlance]. <br>
-Description: Crystal structure of human Brachyury (T) G177D variant in complex with DNA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f59 OCA], [http://pdbe.org/6f59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f59 RCSB], [http://www.ebi.ac.uk/pdbsum/6f59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f59 ProSAT]</span></td></tr>
-[[Category: Arrowsmith, C.H]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRAC_HUMAN BRAC_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/BRAC_HUMAN BRAC_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Burgess-Brown, N A]]
+[[Category: Delft, F von]]
+[[Category: Edwards, A]]
+[[Category: Gavard, A E]]
 [[Category: Gileadi, O]]
-[[Category: Newman, J.A]]
-[[Category: Edwards, A]]
 [[Category: Krojer, T]]
-[[Category: Gavard, A.E]]
+[[Category: Newman, J A]]
-[[Category: Von Delft, F]]
+[[Category: Shrestha, L]]
-[[Category: Bountra, C]]
+[[Category: Brachyury]]
+[[Category: Chordoma]]
+[[Category: T-box]]
+[[Category: Transcription]]