Unusual sequence numbering: Difference between revisions
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Sometimes a range of sequence numbers is skipped when numbering a continuous protein chain. There is no gap in the protein chain, but merely a discontinuity in the numbering of the chain. In the case of antibody [http://firstglance.jmol.org/fgij/fg.htm?1igy 1igy] ([[1igy]]), the sequence is numbered according to the Kabat scheme, relative to a reference sequence. Chain B begins with 1 and ends with 474 but contains only 444 residues (none are missing coordinates due to disorder). In chain B, residue 97 is followed by residue 100, '''skipping numbers 98-99'''. Only the numbers are skipped. No residues are missing. Residue 97 is peptide-bonded to residue 100. There are four residues 100, with insertion codes H, I, J, K. Residue 157 is followed by residue 162, '''skipping numbers 158-161'''. '''Also skipped are sequence numbers 170, 181-182, 197, 201, 207, 224-225, 233-234, 293-294, 297-298, 315-316, 356, 362, 376, 380, 403-404, 409, 412-413, 429, 431-432''', and probably more. | Sometimes a range of sequence numbers is skipped when numbering a continuous protein chain. There is no gap in the protein chain, but merely a discontinuity in the numbering of the chain. In the case of antibody [http://firstglance.jmol.org/fgij/fg.htm?1igy 1igy] ([[1igy]]), the sequence is numbered according to the Kabat scheme, relative to a reference sequence. Chain B begins with 1 and ends with 474 but contains only 444 residues (none are missing coordinates due to disorder). In chain B, residue 97 is followed by residue 100, '''skipping numbers 98-99'''. Only the numbers are skipped. No residues are missing. Residue 97 is peptide-bonded to residue 100. There are four residues 100, with insertion codes H, I, J, K. Residue 157 is followed by residue 162, '''skipping numbers 158-161'''. '''Also skipped are sequence numbers 170, 181-182, 197, 201, 207, 224-225, 233-234, 293-294, 297-298, 315-316, 356, 362, 376, 380, 403-404, 409, 412-413, 429, 431-432''', and probably more. | ||
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===Missing Residues=== | ===Missing Residues=== | ||
[[Image:Sequence-missing-loop-2ace.png|frame|Excerpt from PDB file 2ace showing gap in sequence numbering due to a missing loop.]] | [[Image:Sequence-missing-loop-2ace.png|frame|Excerpt from PDB file 2ace showing gap in sequence numbering due to a missing loop.]] | ||