UMP/CMP kinase: Difference between revisions

Revision as of 23:34, 26 November 2017

Function

UMP/CMP kinase (UCK) or uridylmonophosphate/cytidylmonophosphate kinase phosphorylates UMP, CMP and deoxy-CMP^[1].

Relevance

Several cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK^[2].

Structure of human UMP/CMP kinase complex with sulfate (PDB entry 1tev)

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3D Structures of UMP/CMP kinase3D Structures of UMP/CMP kinase

Updated on 26-November-2017

2ukd, 3ukd, 1qf9, 5ukd – smUCK + ADP + CMP – slime mold
4ukd – smUCK + ADP + UDP
1uke – smUCK + inhibitor
1tev – UCK – human

ReferencesReferences

↑ Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D. Reaction of human UMP-CMP kinase with natural and analog substrates. Eur J Biochem. 2003 Apr;270(8):1784-90. PMID:12694191
↑ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. PMID:11912132

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

[1] Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D. Reaction of human UMP-CMP kinase with natural and analog substrates. Eur J Biochem. 2003 Apr;270(8):1784-90. PMID:12694191

[2] Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. PMID:11912132

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 == Relevance ==
-everal cytidine and deoxycytidine analogs are important anticancer and antiviral drugs.  These drugs require stepwise phosphorylation to exert their fully therapeutic effect.  This phosphorylation is done by UCK<ref>PMID:11912132</ref>.
+Several cytidine and deoxycytidine analogs are important anticancer and antiviral drugs.  These drugs require stepwise phosphorylation to exert their fully therapeutic effect.  This phosphorylation is done by UCK<ref>PMID:11912132</ref>.
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