Circadian clock protein: Difference between revisions
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<StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'> | <StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'> | ||
'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]]. | '''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then '''KaiC''' binds to '''KaiB'''<ref>PMID:15716247</ref> which inactivates '''KaiA''' and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]]. | ||
Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]). | Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]). | ||
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**[[1v2z]] – SeKaiA C terminal <br /> | **[[1v2z]] – SeKaiA C terminal <br /> | ||
**[[1r8j]] – SeKaiA <br /> | **[[1r8j]] – SeKaiA <br /> | ||
**[[4g86]] – SeKaiA + DBMIB<br /> | **[[4g86]] – SeKaiA + DBMIB<br /> | ||
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**[[1wwj]] – SyKaiB - ''Synechocystis''<br /> | **[[1wwj]] – SyKaiB - ''Synechocystis''<br /> | ||
**[[1vgl]], [[2qke]], [[4kso]] – SeKaiB <br /> | **[[1vgl]], [[2qke]], [[4kso]] – SeKaiB <br /> | ||
**[[5jyt]] – SeKaiB (mutant) - NMR <br /> | |||
**[[5jyv]] – SeKaiB (mutant) + CIKA - NMR <br /> | |||
*KaiC | *KaiC | ||
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**[[4tl8]], [[4tl7]] – SeKaiC N terminal C1 domain<br /> | **[[4tl8]], [[4tl7]] – SeKaiC N terminal C1 domain<br /> | ||
**[[4tl9]], [[4tla]], [[4tlb]], [[4tlc]], [[4tld]], [[4tle]] – SeKaiC N terminal C1 domain (mutant)<br /> | **[[4tl9]], [[4tla]], [[4tlb]], [[4tlc]], [[4tld]], [[4tle]] – SeKaiC N terminal C1 domain (mutant)<br /> | ||
*KaiA+KaiC | |||
**[[1suy]], [[1sv1]] – SeKaiA C terminal + KaiC peptide - NMR <br /> | |||
**[[5c5e]] – SeKaiA + KaiC peptide <br /> | |||
*KaiB+KaiC | |||
**[[5jwo]], [[5jwq]] – SeKaiB (mutant) + KaiC (mutant) <br /> | |||
*KaiA+KaiB+KaiC | |||
**[[5n8y]] – SeKaiA + SeKaiB + KaiC – Cryo EM <br /> | |||
**[[5jwr]] – SeKaiA (mutant) + SeKaiB (mutant) + KaiC (mutant) <br /> | |||
}} | }} | ||