2bfr: Difference between revisions

Revision as of 20:13, 3 May 2008

THE MACRO DOMAIN IS AN ADP-RIBOSE BINDING MODULE

OverviewOverview

The ADP-ribosylation of proteins is an important post-translational modification that occurs in a variety of biological processes, including DNA repair, transcription, chromatin biology and long-term memory formation. Yet no protein modules are known that specifically recognize the ADP-ribose nucleotide. We provide biochemical and structural evidence that macro domains are high-affinity ADP-ribose binding modules. Our structural analysis reveals a conserved ligand binding pocket among the macro domain fold. Consistently, distinct human macro domains retain their ability to bind ADP-ribose. In addition, some macro domain proteins also recognize poly-ADP-ribose as a ligand. Our data suggest an important role for proteins containing macro domains in the biology of ADP-ribose.

About this StructureAbout this Structure

2BFR is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

ReferenceReference

The macro domain is an ADP-ribose binding module., Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M, Ladurner AG, EMBO J. 2005 Jun 1;24(11):1911-20. Epub 2005 May 19. PMID:15902274 Page seeded by OCA on Sat May 3 20:13:52 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2bfr.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2bfr |SIZE=350|CAPTION= <scene name='initialview01'>2bfr</scene>, resolution 2.5&Aring;
+The line below this paragraph, containing "STRUCTURE_2bfr", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2bfr|  PDB=2bfr  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bfr OCA], [http://www.ebi.ac.uk/pdbsum/2bfr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bfr RCSB]</span>
-}}
 '''THE MACRO DOMAIN IS AN ADP-RIBOSE BINDING MODULE'''
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 [[Category: Pugieux, C.]]
 [[Category: Sait, F.]]
-[[Category: crystal structure p-loop]]
+[[Category: Crystal structure p-loop]]
-[[Category: histone macroh2a]]
+[[Category: Histone macroh2a]]
-[[Category: hydrolase]]
+[[Category: Hydrolase]]
-[[Category: macro_h2a domain/hydrolase]]
+[[Category: Macro_h2a domain/hydrolase]]
-[[Category: nucleotide]]
+[[Category: Nucleotide]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:13:52 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:05:48 2008''