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'''Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor''' | '''Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. | |||
==Reference== | ==Reference== | ||
Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor., Bosch J, Turley S, Daly TM, Bogh SM, Villasmil ML, Roach C, Zhou N, Morrisey JM, Vaidya AB, Bergman LW, Hol WG, Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4852-7. Epub 2006 Mar 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16547135 16547135] | Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor., Bosch J, Turley S, Daly TM, Bogh SM, Villasmil ML, Roach C, Zhou N, Morrisey JM, Vaidya AB, Bergman LW, Hol WG, Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4852-7. Epub 2006 Mar 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16547135 16547135] | ||
[[Category: Bosch, J.]] | [[Category: Bosch, J.]] | ||
[[Category: Hol, W G.J.]] | [[Category: Hol, W G.J.]] | ||
[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]] | [[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]] | ||
[[Category: Turley, S.]] | [[Category: Turley, S.]] | ||
[[Category: | [[Category: Myoa]] | ||
[[Category: | [[Category: Myoa tail interacting protein]] | ||
[[Category: | [[Category: Myosin a-tail]] | ||
[[Category: | [[Category: Protein structure initiative mtip]] | ||
[[Category: | [[Category: Psi]] | ||
[[Category: | [[Category: Sgpp]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: | [[Category: Structural genomics of pathogenic protozoa consortium]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:29:18 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 19:29, 3 May 2008
Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor
OverviewOverview
The causative agents of malaria have developed a sophisticated machinery for entering multiple cell types in the human and insect hosts. In this machinery, a critical interaction occurs between the unusual myosin motor MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one crystal structure that shows three different conformations of Plasmodium MTIP, one of these in complex with the MyoA-tail, which reveal major conformational changes in the C-terminal domain of MTIP upon binding the MyoA-tail helix, thereby creating several hydrophobic pockets in MTIP that are the recipients of key hydrophobic side chains of MyoA. Because we also show that the MyoA helix is able to block parasite growth, this provides avenues for designing antimalarials.
About this StructureAbout this Structure
Full crystallographic information is available from OCA.
ReferenceReference
Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor., Bosch J, Turley S, Daly TM, Bogh SM, Villasmil ML, Roach C, Zhou N, Morrisey JM, Vaidya AB, Bergman LW, Hol WG, Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4852-7. Epub 2006 Mar 17. PMID:16547135 Page seeded by OCA on Sat May 3 19:29:18 2008