2arw: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2arw.gif|left|200px]] | [[Image:2arw.gif|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_2arw", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
| | or leave the SCENE parameter empty for the default display. | ||
| | --> | ||
{{STRUCTURE_2arw| PDB=2arw | SCENE= }} | |||
}} | |||
'''The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor''' | '''The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor''' | ||
| Line 31: | Line 28: | ||
[[Category: Rose-John, S.]] | [[Category: Rose-John, S.]] | ||
[[Category: Schwantner, A.]] | [[Category: Schwantner, A.]] | ||
[[Category: | [[Category: Fibronectin-type iii like]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:24:09 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 19:24, 3 May 2008
The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor
OverviewOverview
The members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains. These receptors have a characteristic cytokine receptor homology region consisting of two fibronectin type III-like domains defined by a set of four conserved cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On target cells, interleukin-6 (IL-6) initially binds to its cognate alpha-receptor and subsequently to a homodimer of the signal transducer receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular domains. The N-terminal immunoglobulin-like domain is not involved in ligand binding, whereas the third membrane-proximal fibronectin-like domain (IL-6R-D3) accounts for more than 90% of the binding energy to IL-6. Here, we present the solution structure of the IL-6R-D3 domain solved by multidimensional heteronuclear NMR spectroscopy.
About this StructureAbout this Structure
2ARW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor., Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grotzinger J, Biol Chem. 2006 Sep;387(9):1255-9. PMID:16972794 Page seeded by OCA on Sat May 3 19:24:09 2008