4j7y: Difference between revisions

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 ==Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis==
-<StructureSection load='4j7y' size='340' side='right' caption='[[4j7y]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+<StructureSection load='4j7y' size='340' side='right'caption='[[4j7y]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4j7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J7Y FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4j7y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7Y FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1JP:D-GAMMA-GLUTAMYL-(Z)-N-(CARBOXYMETHYLIDENE)-S-[(2R)-2-HYDROXY-4-PHENYLBUTYL]-L-CYSTEINAMIDE'>1JP</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1JP:D-GAMMA-GLUTAMYL-(Z)-N-(CARBOXYMETHYLIDENE)-S-[(2R)-2-HYDROXY-4-PHENYLBUTYL]-L-CYSTEINAMIDE'>1JP</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uui|2uui]], [[2uuh|2uuh]], [[4j7t|4j7t]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7y OCA], [https://pdbe.org/4j7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7y RCSB], [https://www.ebi.ac.uk/pdbsum/4j7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7y ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LTC4S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-C(4)_synthase Leukotriene-C(4) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.20 4.4.1.20] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7y OCA], [http://pdbe.org/4j7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j7y RCSB], [http://www.ebi.ac.uk/pdbsum/4j7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7y ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
+[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
 == Function ==
-[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
+[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 20: @@
 </div>
 <div class="pdbe-citations 4j7y" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Leukotriene C4 synthase|Leukotriene C4 synthase]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Haeggstrom, J Z]]
+[[Category: Large Structures]]
-[[Category: Niegowski, D]]
+[[Category: Haeggstrom JZ]]
-[[Category: Rinaldo-Matthis, A]]
+[[Category: Niegowski D]]
-[[Category: Leukotriene c4 synthase]]
+[[Category: Rinaldo-Matthis A]]
-[[Category: Lipid biosynthesis]]
-[[Category: Lyase]]
-[[Category: Product analog]]