2ak2: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2ak2.jpg|left|200px]] | [[Image:2ak2.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_2ak2", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
or leave the SCENE parameter empty for the default display. | |||
| | --> | ||
| | {{STRUCTURE_2ak2| PDB=2ak2 | SCENE= }} | ||
}} | |||
'''ADENYLATE KINASE ISOENZYME-2''' | '''ADENYLATE KINASE ISOENZYME-2''' | ||
| Line 28: | Line 25: | ||
[[Category: Schlauderer, G J.]] | [[Category: Schlauderer, G J.]] | ||
[[Category: Schulz, G E.]] | [[Category: Schulz, G E.]] | ||
[[Category: | [[Category: Nucleoside monophosphate kinase]] | ||
[[Category: | [[Category: Phosphotransferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:08:54 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 19:08, 3 May 2008
ADENYLATE KINASE ISOENZYME-2
OverviewOverview
In vertebrates, there are different adenylate kinases in the compartments cytosol, mitochondrial intermembrane space, and mitochondrial matrix. Here, we report the spatial structure of the intermembrane species established in two crystal forms by X-ray diffraction analyses at 1.92 and 2.1 A resolution. In both structures, the enzyme is unligated, and thus in an "open" conformation. The enzyme was prepared from bovine liver, containing at least five variants arisen from posttranscriptional and posttranslational modifications. It could only be crystallized after removing some of these variants. A comparison with the known structures of the adenylate kinases from cytosol and mitochondrial matrix reveals structural differences that should play a role in protein targeting because none of these enzymes contains a cleavable signal peptide. A further comparison with adenylate kinases from Gram-positive bacteria showed that the structural Zn2+ ion of these species is replaced by a strictly conserved assembly of hydrogen bonded residues.
About this StructureAbout this Structure
2AK2 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
ReferenceReference
The structure of bovine mitochondrial adenylate kinase: comparison with isoenzymes in other compartments., Schlauderer GJ, Schulz GE, Protein Sci. 1996 Mar;5(3):434-41. PMID:8868479 Page seeded by OCA on Sat May 3 19:08:54 2008