4izk: Difference between revisions

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==Crystal structure of yellowtail ascites virus VP4 protease active site mutant (K674A) reveals both an acyl-enzyme complex and an empty active site==
==Crystal structure of yellowtail ascites virus VP4 protease active site mutant (K674A) reveals both an acyl-enzyme complex and an empty active site==
<StructureSection load='4izk' size='340' side='right' caption='[[4izk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4izk' size='340' side='right'caption='[[4izk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4izk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yellowtail_ascites_virus_-_y-6 Yellowtail ascites virus - y-6]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4hhc 4hhc] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3rbp 3rbp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IZK FirstGlance]. <br>
<table><tr><td colspan='2'>[[4izk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yellowtail_ascites_virus_-_Y-6 Yellowtail ascites virus - Y-6]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4hhc 4hhc] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3rbp 3rbp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IZK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4izk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4izk OCA], [https://pdbe.org/4izk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4izk RCSB], [https://www.ebi.ac.uk/pdbsum/4izk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4izk ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4izj|4izj]], [[2gef|2gef]], [[2pnl|2pnl]], [[2pnm|2pnm]], [[3p06|3p06]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VIRAL PROTEIN 4 (VP4) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=360000 Yellowtail ascites virus - Y-6])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Infectious_pancreatic_necrosis_birnavirus_Vp4_peptidase Infectious pancreatic necrosis birnavirus Vp4 peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.115 3.4.21.115] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4izk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4izk OCA], [http://pdbe.org/4izk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4izk RCSB], [http://www.ebi.ac.uk/pdbsum/4izk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4izk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P89521_9VIRU P89521_9VIRU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4izk" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4izk" style="background-color:#fffaf0;"></div>
==See Also==
*[[Rabphilin|Rabphilin]]
*[[Virus protease 3D structures|Virus protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Infectious pancreatic necrosis birnavirus Vp4 peptidase]]
[[Category: Large Structures]]
[[Category: Yellowtail ascites virus - y-6]]
[[Category: Yellowtail ascites virus - Y-6]]
[[Category: Chung, I Y.W]]
[[Category: Chung IYW]]
[[Category: Paetzel, M]]
[[Category: Paetzel M]]
[[Category: Acyl-enzyme]]
[[Category: Alpha-beta protein fold]]
[[Category: Birnavirus]]
[[Category: Hydrolase]]
[[Category: Lysine general base]]
[[Category: Product complex]]
[[Category: Serine-lysine dyad mechanism]]
[[Category: Viral protease]]

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