2ahm: Difference between revisions

Revision as of 19:03, 3 May 2008

Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer

OverviewOverview

Coronavirus replication and transcription machinery involves multiple virus-encoded nonstructural proteins (nsp). We report the crystal structure of the hexadecameric nsp7-nsp8 supercomplex from the severe acute respiratory syndrome coronavirus at 2.4-angstroms resolution. nsp8 has a novel 'golf-club' fold with two conformations. The supercomplex is a unique hollow, cylinder-like structure assembled from eight copies of nsp8 and held tightly together by eight copies of nsp7. With an internal diameter of approximately 30 angstroms, the central channel has dimensions and positive electrostatic properties favorable for nucleic acid binding, implying that its role is to confer processivity on RNA-dependent RNA polymerase.

About this StructureAbout this Structure

2AHM is a Protein complex structure of sequences from Human sars coronavirus. Full crystallographic information is available from OCA.

ReferenceReference

Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer., Zhai Y, Sun F, Li X, Pang H, Xu X, Bartlam M, Rao Z, Nat Struct Mol Biol. 2005 Nov;12(11):980-6. PMID:16228002 Page seeded by OCA on Sat May 3 19:03:28 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2ahm.gif|left|200px]]
- {{Structure
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 '''Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer'''
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 [[Category: Sun, F.]]
 [[Category: Zhai, Y J.]]
-[[Category: coronavirus]]
+[[Category: Coronavirus]]
-[[Category: hexadecamer]]
+[[Category: Hexadecamer]]
-[[Category: non-structural protein]]
+[[Category: Non-structural protein]]
-[[Category: nsp7]]
+[[Category: Nsp7]]
-[[Category: nsp8]]
+[[Category: Nsp8]]
-[[Category: sars-cov]]
+[[Category: Sars-cov]]
-[[Category: super-complex]]
+[[Category: Super-complex]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:03:28 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:52:47 2008''