2agg: Difference between revisions
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'''succinyl-AAPK-trypsin acyl-enzyme at 1.28 A resolution''' | '''succinyl-AAPK-trypsin acyl-enzyme at 1.28 A resolution''' | ||
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[[Category: Lu, C J.]] | [[Category: Lu, C J.]] | ||
[[Category: Radisky, E S.]] | [[Category: Radisky, E S.]] | ||
[[Category: | [[Category: Acyl-enzyme]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: | [[Category: Peptidase]] | ||
[[Category: | [[Category: Proteinase]] | ||
[[Category: | [[Category: Serine protease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:01:10 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 19:01, 3 May 2008
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| 2agg, resolution 1.28Å () | |||||||||
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| Ligands: | , | ||||||||
| Non-Standard Residues: | |||||||||
| Activity: | Trypsin, with EC number 3.4.21.4 | ||||||||
| Related: | 2age, 2agi, 2ah4 | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
succinyl-AAPK-trypsin acyl-enzyme at 1.28 A resolution
OverviewOverview
Atomic resolution structures of trypsin acyl-enzymes and a tetrahedral intermediate analog, along with previously solved structures representing the Michaelis complex, are used to reconstruct events in the catalytic cycle of this classic serine protease. Structural comparisons provide insight into active site adjustments involved in catalysis. Subtle motions of the catalytic serine and histidine residues coordinated with translation of the substrate reaction center are seen to favor the forward progress of the acylation reaction. The structures also clarify the attack trajectory of the hydrolytic water in the deacylation reaction.
About this StructureAbout this Structure
2AGG is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
ReferenceReference
Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates., Radisky ES, Lee JM, Lu CJ, Koshland DE Jr, Proc Natl Acad Sci U S A. 2006 May 2;103(18):6835-40. Epub 2006 Apr 24. PMID:16636277 Page seeded by OCA on Sat May 3 19:01:10 2008