5k9m: Difference between revisions
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==Crystal Structure of PriB Binary Complex with Product Diphosphate== | ==Crystal Structure of PriB Binary Complex with Product Diphosphate== | ||
<StructureSection load='5k9m' size='340' side='right' caption='[[5k9m]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='5k9m' size='340' side='right'caption='[[5k9m]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5k9m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._rm-5-8 Streptomyces sp. rm-5-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K9M FirstGlance]. <br> | <table><tr><td colspan='2'>[[5k9m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._rm-5-8 Streptomyces sp. rm-5-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K9M FirstGlance]. <br> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Streptomyces sp. rm-5-8]] | [[Category: Streptomyces sp. rm-5-8]] | ||
[[Category: Benach, J]] | [[Category: Benach, J]] | ||
Revision as of 12:13, 4 December 2019
Crystal Structure of PriB Binary Complex with Product DiphosphateCrystal Structure of PriB Binary Complex with Product Diphosphate
Structural highlights
Publication Abstract from PubMedThis study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug. Structure and specificity of a permissive bacterial C-prenyltransferase.,Elshahawi SI, Cao H, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN Jr, Thorson JS, Singh S Nat Chem Biol. 2017 Feb 6. doi: 10.1038/nchembio.2285. PMID:28166207[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Large Structures
- Streptomyces sp. rm-5-8
- Benach, J
- Cao, H
- Elshahawi, S
- Koss, J W
- Morisco, L L
- NatPro, Enzyme Discovery for Natural Product Biosynthesis
- Phillips, G N
- Thorson, J S
- Wasserman, S R
- Abba family
- Diphosphate
- Enzyme discovery for natural product biosynthesis
- Indole-pt
- Natpro
- Prenyltransferase
- PSI, Protein structure initiative
- Pt fold
- Structural genomic
- Transferase