4zwv: Difference between revisions
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==Crystal Structure of Aminotransferase AtmS13 from Actinomadura melliaura== | ==Crystal Structure of Aminotransferase AtmS13 from Actinomadura melliaura== | ||
<StructureSection load='4zwv' size='340' side='right' caption='[[4zwv]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='4zwv' size='340' side='right'caption='[[4zwv]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4zwv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/'actinomadura_melliaura' 'actinomadura melliaura']. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4rxk 4rxk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZWV FirstGlance]. <br> | <table><tr><td colspan='2'>[[4zwv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/'actinomadura_melliaura' 'actinomadura melliaura']. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4rxk 4rxk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZWV FirstGlance]. <br> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Actinomadura melliaura]] | [[Category: Actinomadura melliaura]] | ||
[[Category: Large Structures]] | |||
[[Category: Bigelow, L]] | [[Category: Bigelow, L]] | ||
[[Category: Endres, M]] | [[Category: Endres, M]] | ||
Revision as of 11:51, 4 December 2019
Crystal Structure of Aminotransferase AtmS13 from Actinomadura melliauraCrystal Structure of Aminotransferase AtmS13 from Actinomadura melliaura
Structural highlights
Publication Abstract from PubMedAT2433 from Actinomadura melliaura is an indolocarbazole antitumor antibiotic structurally distinguished by its unique aminodideoxypentose-containing disaccharide moiety. The corresponding sugar nucleotide-based biosynthetic pathway for this unusual sugar derives from comparative genomics where AtmS13 has been suggested as the contributing sugar aminotransferase (SAT). Determination of the AtmS13 X-ray structure at 1.50 A resolution reveals it as a member of the aspartate aminotransferase fold type I (AAT-I). Structural comparisons of AtmS13 with homologous SATs that act upon similar substrates implicate potential active site residues that contribute to distinctions in sugar C5 (hexose versus pentose) and/or sugar C2 (deoxy versus hydroxyl) substrate specificity. This article is protected by copyright. All rights reserved. Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.,Singh S, Kim Y, Wang F, Bigelow L, Endres M, Kharel MK, Babnigg G, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Proteins. 2015 Jun 9. doi: 10.1002/prot.24844. PMID:26061967[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Actinomadura melliaura
- Large Structures
- Bigelow, L
- Endres, M
- Joachimiak, A
- Kim, Y
- Structural genomic
- NatPro, Enzyme Discovery for Natural Product Biosynthesis
- Phillips, G N
- Wang, F
- Aminotransferase
- Enzyme discovery for natural product biosynthesis
- Mcsg
- Natpro
- PSI, Protein structure initiative
- Psi-biology
- Transferase