4y5y: Difference between revisions

<StructureSection load='4y5y' size='340' side='right'caption='[[4y5y]], [[Resolution|resolution]] 2.85&Aring;' scene=''>

<table><tr><td colspan='2'>[[4y5y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y5Y FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5y OCA], [https://pdbe.org/4y5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y5y RCSB], [https://www.ebi.ac.uk/pdbsum/4y5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y5y ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/EPOR_HUMAN EPOR_HUMAN] Defects in EPOR are the cause of familial erythrocytosis type 1 (ECYT1) [MIM:[https://omim.org/entry/133100 133100]. ECYT1 is an autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin and hematocrit, hypersensitivity of erythroid progenitors to erythropoietin, erythropoietin low serum levels, and no increase in platelets nor leukocytes. It has a relatively benign course and does not progress to leukemia.<ref>PMID:8506290</ref> <ref>PMID:8174675</ref> <ref>PMID:8608241</ref>  

[https://www.uniprot.org/uniprot/EPOR_HUMAN EPOR_HUMAN] Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.  Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Garcia KC]]

[[Category: Guo F]]

[[Category: Jude KM]]

[[Category: Moraga I]]

[[Category: Ozkan E]]