3l5c: Difference between revisions

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 ==Structure of BACE Bound to SCH723871==
-<StructureSection load='3l5c' size='340' side='right' caption='[[3l5c]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='3l5c' size='340' side='right'caption='[[3l5c]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3l5c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L5C FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3l5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L5C FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BDQ:1-(4-CYANOPHENYL)-3-(4-{[(2Z,4R)-2-IMINO-4-METHYL-4-(2-METHYLPROPYL)-5-OXOIMIDAZOLIDIN-1-YL]METHYL}BENZYL)UREA'>BDQ</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l58|3l58]], [[3l59|3l59]], [[3l5b|3l5b]], [[3l5d|3l5d]], [[3l5e|3l5e]], [[3l5f|3l5f]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BDQ:1-(4-CYANOPHENYL)-3-(4-{[(2Z,4R)-2-IMINO-4-METHYL-4-(2-METHYLPROPYL)-5-OXOIMIDAZOLIDIN-1-YL]METHYL}BENZYL)UREA'>BDQ</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l5c OCA], [https://pdbe.org/3l5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l5c RCSB], [https://www.ebi.ac.uk/pdbsum/3l5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l5c ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l5c OCA], [http://pdbe.org/3l5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l5c RCSB], [http://www.ebi.ac.uk/pdbsum/3l5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l5c ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
+[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l5/3l5c_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l5/3l5c_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 31: / Line 29: @@
 </div>
 <div class="pdbe-citations 3l5c" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Beta secretase 3D structures|Beta secretase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Memapsin 2]]
+[[Category: Large Structures]]
-[[Category: Strickland, C]]
+[[Category: Strickland C]]
-[[Category: Zhu, Z]]
+[[Category: Zhu Z]]
-[[Category: Alternative splicing]]
-[[Category: Alzheimer]]
-[[Category: Aspartyl protease]]
-[[Category: Bace1]]
-[[Category: Disulfide bond]]
-[[Category: Endoplasmic reticulum]]
-[[Category: Endosome]]
-[[Category: Glycoprotein]]
-[[Category: Golgi apparatus]]
-[[Category: Hydrolase]]
-[[Category: Membrane]]
-[[Category: Polymorphism]]
-[[Category: Protease]]
-[[Category: Transmembrane]]
-[[Category: Zymogen]]