1zr5: Difference between revisions

Revision as of 17:57, 3 May 2008

Crystal structure of the macro-domain of human core histone variant macroH2A1.2

OverviewOverview

Histone macroH2A is a hallmark of mammalian heterochromatin. Here we show that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose (OAADPR) through its macro domain. The 1.6-A crystal structure and mutants reveal how the metabolite is recognized. Mutually exclusive exon use in the gene H2AFY produces macroH2A1.2, whose tissue distribution differs. MacroH2A1.2 shows only subtle structural changes but cannot bind nucleotides. Alternative splicing may thus regulate the binding of nicotinamide adenine dinucleotide (NAD) metabolites to chromatin.

About this StructureAbout this Structure

1ZR5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Splicing regulates NAD metabolite binding to histone macroH2A., Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG, Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19. PMID:15965484 Page seeded by OCA on Sat May 3 17:57:57 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1zr5.gif|left|200px]]
- {{Structure
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zr5 OCA], [http://www.ebi.ac.uk/pdbsum/1zr5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zr5 RCSB]</span>
-}}
 '''Crystal structure of the macro-domain of human core histone variant macroH2A1.2'''
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 [[Category: Pugieux, C.]]
 [[Category: Scheffzek, K.]]
-[[Category: a1pp]]
+[[Category: A1pp]]
-[[Category: chromatin]]
+[[Category: Chromatin]]
-[[Category: histone]]
+[[Category: Histone]]
-[[Category: macro-domain]]
+[[Category: Macro-domain]]
-[[Category: p-loop]]
+[[Category: P-loop]]
-[[Category: splicing]]
+[[Category: Splicing]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:57:57 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:40:31 2008''