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==Crystal Structure of H400V mutant TTHA0252 from Thermus thermophilus HB8==
==Crystal Structure of H400V mutant TTHA0252 from Thermus thermophilus HB8==
<StructureSection load='3ie2' size='340' side='right' caption='[[3ie2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='3ie2' size='340' side='right'caption='[[3ie2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ie2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yvd 2yvd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IE2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ie2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yvd 2yvd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IE2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2dkf|2dkf]], [[3a4y|3a4y]], [[3idz|3idz]], [[3ie0|3ie0]], [[3ie1|3ie1]], [[3iek|3iek]], [[3iel|3iel]], [[3iem|3iem]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2dkf|2dkf]], [[3a4y|3a4y]], [[3idz|3idz]], [[3ie0|3ie0]], [[3ie1|3ie1]], [[3iek|3iek]], [[3iel|3iel]], [[3iem|3iem]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTHA0252 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTHA0252 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ie2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ie2 OCA], [http://pdbe.org/3ie2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ie2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ie2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ie2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ie2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ie2 OCA], [https://pdbe.org/3ie2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ie2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ie2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ie2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RNSE_THET8 RNSE_THET8]] Has endoribonuclease activity towards 23S and 16S rRNA (in vitro).  
[[https://www.uniprot.org/uniprot/RNSE_THET8 RNSE_THET8]] Has endoribonuclease activity towards 23S and 16S rRNA (in vitro).  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ie/3ie2_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ie/3ie2_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Temp|Temp]]
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Thet8]]
[[Category: Thet8]]
[[Category: Ishikawa, H]]
[[Category: Ishikawa, H]]

Revision as of 10:47, 10 November 2021

Crystal Structure of H400V mutant TTHA0252 from Thermus thermophilus HB8Crystal Structure of H400V mutant TTHA0252 from Thermus thermophilus HB8

Structural highlights

3ie2 is a 4 chain structure with sequence from Thet8. This structure supersedes the now removed PDB entry 2yvd. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Gene:TTHA0252 (THET8)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RNSE_THET8] Has endoribonuclease activity towards 23S and 16S rRNA (in vitro).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3ie2, resolution 2.80Å

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OCA
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