6b4f: Difference between revisions

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'''Unreleased structure'''


The entry 6b4f is ON HOLD until Paper Publication
==Crystal structure of human Gle1 CTD-Nup42 GBM complex==
 
<StructureSection load='6b4f' size='340' side='right' caption='[[6b4f]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6b4f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B4F FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b4f OCA], [http://pdbe.org/6b4f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b4f RCSB], [http://www.ebi.ac.uk/pdbsum/6b4f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b4f ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/GLE1_HUMAN GLE1_HUMAN]] Lethal arthrogryposis - anterior horn cell disease;Lethal congenital contracture syndrome type 1. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/GLE1_HUMAN GLE1_HUMAN]] Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).<ref>PMID:12668658</ref> <ref>PMID:16000379</ref> <ref>PMID:9618489</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cai, S W]]
[[Category: Correia, A R]]
[[Category: Hoelz, A]]
[[Category: Huber, F M]]
[[Category: Jette, C A]]
[[Category: Lin, D H]]
[[Category: Complex]]
[[Category: Dead-box helicase]]
[[Category: Mrna export]]
[[Category: Nuclear pore complex]]
[[Category: Transport protein]]

Revision as of 08:47, 20 June 2018

Crystal structure of human Gle1 CTD-Nup42 GBM complexCrystal structure of human Gle1 CTD-Nup42 GBM complex

Structural highlights

6b4f is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[GLE1_HUMAN] Lethal arthrogryposis - anterior horn cell disease;Lethal congenital contracture syndrome type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[GLE1_HUMAN] Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).[1] [2] [3]

References

  1. ↑ Kendirgi F, Barry DM, Griffis ER, Powers MA, Wente SR. An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export. J Cell Biol. 2003 Mar 31;160(7):1029-40. doi: 10.1083/jcb.200211081. PMID:12668658 doi:http://dx.doi.org/10.1083/jcb.200211081
  2. ↑ Kendirgi F, Rexer DJ, Alcazar-Roman AR, Onishko HM, Wente SR. Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA. Mol Biol Cell. 2005 Sep;16(9):4304-15. Epub 2005 Jul 6. PMID:16000379 doi:http://dx.doi.org/E04-11-0998
  3. ↑ Watkins JL, Murphy R, Emtage JL, Wente SR. The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6779-84. PMID:9618489

6b4f, resolution 2.81Å

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