Pyruvate phosphate dikinase: Difference between revisions
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<StructureSection load='' size='340' side='right' caption='Pyruvate phosphate dikinase complex with sulfate (PDB code [[1dik]])' scene=''> | <StructureSection load='1dik' size='340' side='right' caption='Pyruvate phosphate dikinase complex with sulfate (PDB code [[1dik]])' scene=''> | ||
==Pyruvate Phosphate Dikinase - a Molecular Machine== | ==Pyruvate Phosphate Dikinase - a Molecular Machine== | ||
'''Pyruvate phosphate dikinase''' (PPDK) is an enzyme that catalyzes the inter-conversion of adenosine triphosphate (ATP), phosphate (P<sub>i</sub>), and pyruvate with adenine monophosphate (AMP), pyrophosphate (PP<sub>i</sub>), and phosphoenolpyruvate (PEP) in the presence of magnesium and potassium/sodium ions (Mg<sup>2+</sup> and K<sup>+</sup>/Na<sup>+</sup>). The three-step reversible reaction proceeds via phosphoenzyme and pyrophosphoenzyme intermediates with a histidine residue serving as the phosphocarrier: | '''Pyruvate phosphate dikinase''' (PPDK) is an enzyme that catalyzes the inter-conversion of adenosine triphosphate (ATP), phosphate (P<sub>i</sub>), and pyruvate with adenine monophosphate (AMP), pyrophosphate (PP<sub>i</sub>), and phosphoenolpyruvate (PEP) in the presence of magnesium and potassium/sodium ions (Mg<sup>2+</sup> and K<sup>+</sup>/Na<sup>+</sup>). The three-step reversible reaction proceeds via phosphoenzyme and pyrophosphoenzyme intermediates with a histidine residue serving as the phosphocarrier: | ||