Quinone reductase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

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 <StructureSection load='' size='350' scene='2f1o/Com_view/2'  caption='NADPH dehydrogenase complex with FAD (red) and dicoumarol (blue) [[2f1o]]'>
 {{Clear}}
+__TOC__
+==Function==
 '''Quinone reductase type 1 (QR1)''' reduces quinines to the non-toxic hydroquinone. '''Quinone reductase type 2 (QR2)''' catalyzes the reduction of adrenochrome.    The '''sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria.  '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone.  See [[Electron Transport & Oxidative Phosphorylation]].
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 **[[1kbo]], [[1kbq]] – hQR1 + indole derivative<br />
-*Quinone reductase type 2
+*Quinone reductase type 2 or ribosyldihydronicotinamide dehydrogenase [quinone]
-**[[3fw1]], [[1qr2]] – hQR2 - human<br />
+**[[4qod]] – hQR2 - human<br />
-**[[3o2n]], [[3g5m]], [[3gam]] – hQR2 + PET agent<br />
+**[[4qof]] – hQR2 + FMN<br />
-**[[3ovm]], [[3owh]], [[3owx]] – hQR2 + carbamate derivative<br />
+**[[1qr2]], [[3fw1]], [[4qoe]] – hQR2 + FAD<br />
-**[[3ox1]], [[2qx4]], [[2qx6]], [[2qx8]], [[2qx9]], [[2qwx]] – hQR2 + acetamide derivative<br />
+**[[3o2n]], [[3g5m]], [[3gam]] – hQR2 + FAD + PET agent<br />
-**[[3ox2]] - hQR2 + indole derivative<br />
+**[[3ovm]], [[3owh]], [[3owx]] – hQR2 + FAD + carbamate derivative<br />
-**[[3ox3]] - hQR2 + carboxamide derivative<br />
+**[[3ox1]], [[2qx4]], [[2qx6]], [[2qx8]], [[2qx9]], [[2qwx]] – hQR2 + FAD + acetamide derivative<br />
-**[[2qmy]] – hQR2 + adrenochrome<br />
+**[[3ox2]], [[4xdh]], [[4xdg]] - hQR2 + FAD + indole derivative<br />
-**[[2qr2]] – hQR2 + menadione<br />
+**[[3ox3]] - hQR2 + FAD + carboxamide derivative<br />
-**[[2qmz]] – hQR2 + dopamine<br />
+**[[4u7f]], [[4u7g]], [[4u7h]] - hQR2 + FAD + imidazole derivative<br />
-**[[1sg0]] – hQR2 + resveratol<br />
+**[[4zvk]], [[5buc]] - hQR2 + FAD + ethidium<br />
-**[[3nhu]], [[3nhs]], [[3nhr]], [[3nhp]], [[3nhl]], [[3nhk]], [[3nhj]], [[3nhf]], [[3nfr]], [[3nhw]], [[3nhy]], [[3uxe]], [[3uxh]] - hQR2 + quinoline derivative<br />
+**[[4zvm]] - hQR2 + FAD + doxorubicin<br />
-**[[3te7]], [[3tem]], [[3tzb]] – hQR2 + acridine derivative<br />
+**[[2qmy]] – hQR2 + FAD + adrenochrome<br />
-**[[2bzs]], [[1xi2]], [[1zx1]], [[3o73]] – hQR2 + anti-cancer prodrug<br />
+**[[2qr2]] – hQR2 + FAD + menadione<br />
-**[[4fgj]], [[4fgk]], [[4fgl]] – hQR2 + anti-malaria drug<br />
+**[[2qmz]] – hQR2 + FAD + dopamine<br />
-**[[4gqi]], [[4gr9]] – hQR2 + ligand<br />
+**[[4qog]] – hQR2 + FAD + melatonin<br />
+**[[1sg0]], [[4qoh]] – hQR2 + FAD + resveratol<br />
+**[[4qoj]] – hQR2 + FMN + resveratol<br />
+**[[4qoi]] – hQR2 + FMN + melatonin<br />
+**[[3nhu]], [[3nhs]], [[3nhr]], [[3nhp]], [[3nhl]], [[3nhk]], [[3nhj]], [[3nhf]], [[3nfr]], [[3nhw]], [[3nhy]], [[3uxe]], [[3uxh]] - hQR2 + FAD + quinoline derivative<br />
+**[[3te7]], [[3tem]], [[3tzb]], [[4zvl]], [[4zvn]] – hQR2 + FAD + acridine derivative<br />
+**[[2bzs]], [[1xi2]], [[1zx1]], [[3o73]], [[5lbw]], [[5lbz]], [[5lby]] – hQR2 + FAD + anti-cancer prodrug<br />
+**[[4fgj]], [[4fgk]], [[4fgl]] – hQR2 + FAD + anti-malaria drug<br />
+**[[5lbt]], [[5lbu]] – hQR2 + FAD + anti-wart drug<br />
+**[[4gqi]], [[4gr9]] – hQR2 + FAD + ligand<br />
 *Sulfide-quinone reductase