Vpu protein: Difference between revisions

Revision as of 10:57, 18 October 2017

Function

Vpu protein (Vpu) or viral protein U is a viroporin encoded by HIV-1^[1]. Vpu is a multifunctional enhancer of viral particle release^[2].

For details see HIV and accessory proteins.

HIV-1 Vpu protein (dark olive) complex with adapter-related protein complex 1 subunits γ-1 (gold), σ-1a (khaki), μ-1 (olive green), β-1 (green) (PDB code 4p6z)

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3D Structures of Vpu protein3D Structures of Vpu protein

Updated on 18-October-2017

2n28 – Vpu - HIV-1 - NMR
4p6z – Vpu + adapter-related protein complex 1 subunits γ-1, σ-1a, μ-1, β-1 – HIV-1
1pi7, 1pi8, 1pje, 2gof, 2goh – Vpu trans-membrane domain - NMR
1vpu, 2n29, 2k7y – Vpu cytoplasmic domain - NMR
4p6z – Vpu cytoplasmic domain + BST2 + AP-1 core

ReferencesReferences

↑ Gonzalez ME. Vpu Protein: The Viroporin Encoded by HIV-1. Viruses. 2015 Aug 4;7(8):4352-68. doi: 10.3390/v7082824. PMID:26247957 doi:http://dx.doi.org/10.3390/v7082824
↑ Bour S, Strebel K. The HIV-1 Vpu protein: a multifunctional enhancer of viral particle release. Microbes Infect. 2003 Sep;5(11):1029-39. PMID:12941395

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

[1] Gonzalez ME. Vpu Protein: The Viroporin Encoded by HIV-1. Viruses. 2015 Aug 4;7(8):4352-68. doi: 10.3390/v7082824. PMID:26247957 doi:http://dx.doi.org/10.3390/v7082824

[2] Bour S, Strebel K. The HIV-1 Vpu protein: a multifunctional enhancer of viral particle release. Microbes Infect. 2003 Sep;5(11):1029-39. PMID:12941395

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	<StructureSection load='~~4p6z~~' size='340' side='right' caption='HIV-1 Vpu protein (dark olive) complex with adapter-related protein complex 1 subunits γ-1 (gold), σ-1a (khaki), μ-1 (olive green), β-1 (green) (PDB code [[4p6z]])' scene=''>		<StructureSection load='' size='340' side='right' caption='HIV-1 Vpu protein (dark olive) complex with adapter-related protein complex 1 subunits γ-1 (gold), σ-1a (khaki), μ-1 (olive green), β-1 (green) (PDB code [[4p6z]])' scene=''>