1ypq: Difference between revisions
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'''Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex''' | '''Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex''' | ||
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[[Category: Boyington, J C.]] | [[Category: Boyington, J C.]] | ||
[[Category: Park, H.]] | [[Category: Park, H.]] | ||
[[Category: | [[Category: C-type lectin like domain]] | ||
[[Category: | [[Category: Lox-1,ctld]] | ||
[[Category: | [[Category: Nk cell receptor]] | ||
[[Category: | [[Category: Oxidized low density lipoprotein receptor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:37:33 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 16:37, 3 May 2008
Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex
OverviewOverview
The lectin-like oxidized low density lipoprotein receptor-1 (Lox-1) mediates the recognition and internalization of oxidatively modified low density lipoprotein by vascular endothelial cells. This interaction results in a number of pro-atherogenic cellular responses that probably play a significant role in the pathology of atherosclerosis. The 1.4 angstrom crystal structure of the extracellular C-type lectin-like domain of human Lox-1 reveals a heart-shaped homodimer with a ridge of six basic amino acids extending diagonally across the apolar top of Lox-1, a central hydrophobic tunnel that extends through the entire molecule, and an electrostatically neutral patch of 12 charged residues that resides next to the tunnel at each opening. Based on the arrangement of critical binding residues on the Lox-1 structure, we propose a binding mode for the recognition of modified low density lipoprotein and other Lox-1 ligands.
About this StructureAbout this Structure
1YPQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1., Park H, Adsit FG, Boyington JC, J Biol Chem. 2005 Apr 8;280(14):13593-9. Epub 2005 Feb 5. PMID:15695803 Page seeded by OCA on Sat May 3 16:37:33 2008