2zx2: Difference between revisions
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==Rhamnose-binding lectin CSL3== | ==Rhamnose-binding lectin CSL3== | ||
<StructureSection load='2zx2' size='340' side='right' caption='[[2zx2]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2zx2' size='340' side='right'caption='[[2zx2]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2zx2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chum_salmon Chum salmon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZX2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2zx2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chum_salmon Chum salmon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZX2 FirstGlance]. <br> | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/2zx2_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/2zx2_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Chum salmon]] | [[Category: Chum salmon]] | ||
[[Category: Large Structures]] | |||
[[Category: Lee, M]] | [[Category: Lee, M]] | ||
[[Category: Muramoto, K]] | [[Category: Muramoto, K]] | ||
Revision as of 10:29, 31 July 2019
Rhamnose-binding lectin CSL3Rhamnose-binding lectin CSL3
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe crystal structure of the L-rhamnose-binding lectin CSL3 was determined to 1.8 A resolution. This protein is a component of the germline-encoded pattern recognition proteins in innate immunity. CSL3 is a homodimer of two 20 kDa subunits with a dumbbell-like shape overall, in which the N- and C-terminal domains of different subunits form lobe structures connected with flexible linker peptides. The complex structures of the protein with specific carbohydrates demonstrated the importance of the most variable loop region among homologues for the specificity toward oligosaccharides. CSL3 and Shiga-like toxin both use Gb(3) as a cellular receptor to evoke apoptosis. They have very different overall architecture but share the separation distance between carbohydrate-binding sites. An inspection of the structure database suggested that the pseudo-tetrameric structure of CSL3 was unique among the known lectins. This architecture implies this protein might provide a unique tool for further investigations into the relationships between architecture and function of pattern recognition proteins. Structure of rhamnose-binding lectin CSL3: unique pseudo-tetrameric architecture of a pattern recognition protein.,Shirai T, Watanabe Y, Lee MS, Ogawa T, Muramoto K J Mol Biol. 2009 Aug 14;391(2):390-403. Epub 2009 Jun 12. PMID:19524596[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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