6el3: Difference between revisions

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-'''Unreleased structure'''
-The entry 6el3 is ON HOLD
+==Structure of Progesterone 5beta-Reductase from Arabidopsis thaliana in complex with NADP==
+<StructureSection load='6el3' size='340' side='right' caption='[[6el3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6el3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EL3 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Delta(4)-3-oxosteroid_5-beta-reductase Delta(4)-3-oxosteroid 5-beta-reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.3 1.3.1.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6el3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6el3 OCA], [http://pdbe.org/6el3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6el3 RCSB], [http://www.ebi.ac.uk/pdbsum/6el3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6el3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/VEP1_ARATH VEP1_ARATH]] Involved in vascular strand development. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 21-acetyl cortexone, 2-cyclohexenone, but-1-en-3-one, ethyl acrylate, ethylmethacrylate, cortisone and canarigenone as substrates, lower activity with 3-methyl-2-cyclohexenone and 3,5,5-trimethyl-2-cyclohexenone as substrate, and no activity with canarigenin, canarigenin digitoxoside and pregnenolone. May be involved in the formation of 5-beta phytoecdysteroids.<ref>PMID:11917087</ref> <ref>PMID:19166903</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Egerer-Sieber, C]]
+[[Category: Muller, Y A]]
+[[Category: Schmidt, K]]
+[[Category: Homodimer]]
+[[Category: Nadp binding site]]
+[[Category: Oxidoreductase]]