6b3m: Difference between revisions
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==The crystal structure of a broadly-reactive human anti-hemagglutinin stalk antibody (70-1F02) in complex with H5 hemagglutinin== | |||
<StructureSection load='6b3m' size='340' side='right' caption='[[6b3m]], [[Resolution|resolution]] 3.92Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6b3m]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B3M FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b3m OCA], [http://pdbe.org/6b3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b3m RCSB], [http://www.ebi.ac.uk/pdbsum/6b3m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b3m ProSAT]</span></td></tr> | ||
[[Category: Shore, D | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/Q5EP31_9INFA Q5EP31_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Shore, D A]] | |||
[[Category: Stevens, J]] | |||
[[Category: Yang, H]] | [[Category: Yang, H]] | ||
[[Category: | [[Category: Antibody]] | ||
[[Category: Hemagglutinin]] | |||
[[Category: Influenza]] | |||
[[Category: Viral protein-immune system complex]] | |||