5t4x: Difference between revisions

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'''Unreleased structure'''


The entry 5t4x is ON HOLD
==CRYSTAL STRUCTURE OF PDE6D IN APO-STATE==
 
<StructureSection load='5t4x' size='340' side='right' caption='[[5t4x]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
Authors: Qureshi, B.M., Schmidt, A., Scheerer, P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5t4x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T4X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T4X FirstGlance]. <br>
Description: CRYSTAL STRUCTURE OF PDE6D IN APO-STATE
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t4x OCA], [http://pdbe.org/5t4x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t4x RCSB], [http://www.ebi.ac.uk/pdbsum/5t4x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t4x ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Qureshi, B.M]]
== Function ==
[[http://www.uniprot.org/uniprot/PDE6D_MOUSE PDE6D_MOUSE]] Promotes the release of prenylated target proteins from cellular membranes (PubMed:22179043). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22179043). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (PubMed:22179043). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.[UniProtKB:O43924][UniProtKB:Q95142]<ref>PMID:10518933</ref> <ref>PMID:15979089</ref> <ref>PMID:22179043</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Qureshi, B M]]
[[Category: Scheerer, P]]
[[Category: Schmidt, A]]
[[Category: Schmidt, A]]
[[Category: Scheerer, P]]
[[Category: Apo-state]]
[[Category: Cellular trafficking]]
[[Category: Farnesyl]]
[[Category: Geranylgeranyl]]
[[Category: Immunoglobulin-like beta sandwitch]]
[[Category: Lipid binding protein]]
[[Category: Membrane dissociation]]
[[Category: Membrane trafficking]]
[[Category: Pde6 delta]]
[[Category: Phosphodiesterase 6]]
[[Category: Prenyl binding protein]]
[[Category: Ras-gtpase]]
[[Category: Rhodopsin]]
[[Category: Rhodopsin kinase]]
[[Category: Transport protein]]

Revision as of 11:25, 10 January 2018

CRYSTAL STRUCTURE OF PDE6D IN APO-STATECRYSTAL STRUCTURE OF PDE6D IN APO-STATE

Structural highlights

5t4x is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PDE6D_MOUSE] Promotes the release of prenylated target proteins from cellular membranes (PubMed:22179043). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22179043). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (PubMed:22179043). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.[UniProtKB:O43924][UniProtKB:Q95142][1] [2] [3]

References

  1. ↑ Linari M, Hanzal-Bayer M, Becker J. The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner. FEBS Lett. 1999 Sep 10;458(1):55-9. PMID:10518933
  2. ↑ Hanzal-Bayer M, Linari M, Wittinghofer A. Properties of the interaction of Arf-like protein 2 with PDEdelta. J Mol Biol. 2005 Jul 29;350(5):1074-82. PMID:15979089 doi:10.1016/j.jmb.2005.05.036
  3. ↑ Chandra A, Grecco HE, Pisupati V, Perera D, Cassidy L, Skoulidis F, Ismail SA, Hedberg C, Hanzal-Bayer M, Venkitaraman AR, Wittinghofer A, Bastiaens PI. The GDI-like solubilizing factor PDEdelta sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol. 2011 Dec 18;14(2):148-58. doi: 10.1038/ncb2394. PMID:22179043 doi:http://dx.doi.org/10.1038/ncb2394

5t4x, resolution 1.81Å

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