6ayg: Difference between revisions

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-'''Unreleased structure'''
-The entry 6ayg is ON HOLD
+==Human Apo-TRPML3 channel at pH 4.8==
+<StructureSection load='6ayg' size='340' side='right' caption='[[6ayg]], [[Resolution|resolution]] 4.65&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ayg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AYG FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ayg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ayg OCA], [http://pdbe.org/6ayg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ayg RCSB], [http://www.ebi.ac.uk/pdbsum/6ayg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ayg ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MCLN3_HUMAN MCLN3_HUMAN]] Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151).[UniProtKB:Q8R4F0]<ref>PMID:18369318</ref> <ref>PMID:19497048</ref> <ref>PMID:19522758</ref> <ref>PMID:19885840</ref> <ref>PMID:21245134</ref> <ref>PMID:23469151</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Jia, Q]]
+[[Category: Li, H]]
+[[Category: Li, M]]
+[[Category: Li, X]]
+[[Category: Su, D]]
+[[Category: Yang, J]]
+[[Category: Zhou, X]]
+[[Category: Ion channel]]
+[[Category: Lysosomal]]
+[[Category: Transport protein]]
+[[Category: Trp channel]]