1xo5: Difference between revisions
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'''Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein''' | '''Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein''' | ||
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[[Category: Sondek, J.]] | [[Category: Sondek, J.]] | ||
[[Category: Yang, C.]] | [[Category: Yang, C.]] | ||
[[Category: | [[Category: Calcium and integrin binding]] | ||
[[Category: | [[Category: Calmyrin]] | ||
[[Category: | [[Category: Ef-hand]] | ||
[[Category: | [[Category: Kinase interacting protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:17:11 2008'' | |||
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Revision as of 15:17, 3 May 2008
Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein
OverviewOverview
CIB1 (CIB) is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alphaIIbbeta3 integrin and several serine/threonine kinases and potentially modulates their function. The crystal structure for Ca(2+)-bound CIB1 has been determined at 2.0 A resolution and reveals a compact alpha-helical protein containing four EF-hands, the last two of which bind calcium ions in the standard fashion seen in many other EF-hand proteins. CIB1 shares high structural similarity with calcineurin B and the neuronal calcium sensor (NCS) family of EF-hand-containing proteins. Most importantly, like calcineurin B and NCS proteins, which possess a large hydrophobic pocket necessary for ligand binding, CIB1 contains a hydrophobic pocket that has been implicated in ligand binding by previous mutational analysis. However, unlike several NCS proteins, Ca(2+)-bound CIB1 is largely monomeric whether bound to a relevant peptide ligand or ligand-free. Differences in structure, oligomeric state, and phylogeny define a new family of CIB1-related proteins that extends from arthropods to humans.
About this StructureAbout this Structure
1XO5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins., Gentry HR, Singer AU, Betts L, Yang C, Ferrara JD, Sondek J, Parise LV, J Biol Chem. 2005 Mar 4;280(9):8407-15. Epub 2004 Dec 1. PMID:15574431 Page seeded by OCA on Sat May 3 15:17:11 2008