1xe8: Difference between revisions

Revision as of 14:54, 3 May 2008

Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly roll fold.

OverviewOverview

We determined the three-dimensional crystal structure of the protein YML079wp, encoded by a hypothetical open reading frame from Saccharomyces cerevisiae to a resolution of 1.75 A. The protein has no close homologs and its molecular and cellular functions are unknown. The structure of the protein is a jelly-roll fold consisting of ten beta-strands organized in two parallel packed beta-sheets. The protein has strong structural resemblance to the plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) but also to some plant and bacterial enzymes (epimerase, germin). The protein forms homodimers in the crystal, confirming measurements of its molecular mass in solution. Two monomers have their beta-sheet packed together to form the dimer. The presence of a hydrophobic ligand in a well conserved pocket inside the barrel and local sequence similarity with bacterial epimerases may suggest a biochemical function for this protein.

About this StructureAbout this Structure

1XE8 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly-roll fold., Zhou CZ, Meyer P, Quevillon-Cheruel S, De La Sierra-Gallay IL, Collinet B, Graille M, Blondeau K, Francois JM, Leulliot N, Sorel I, Poupon A, Janin J, Van Tilbeurgh H, Protein Sci. 2005 Jan;14(1):209-15. PMID:15608122 Page seeded by OCA on Sat May 3 14:54:57 2008

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OCA

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 [[Image:1xe8.gif|left|200px]]
- {{Structure
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-|GENE= YML079w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xe8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xe8 OCA], [http://www.ebi.ac.uk/pdbsum/1xe8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xe8 RCSB]</span>
-}}
 '''Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly roll fold.'''
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 [[Category: Tilbeurgh, H Van.]]
 [[Category: Zhou, C Z.]]
-[[Category: cupin superfamily]]
+[[Category: Cupin superfamily]]
-[[Category: jelly roll motif]]
+[[Category: Jelly roll motif]]
-[[Category: s. cerevisiae]]
+[[Category: S. cerevisiae]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
-[[Category: yml079wp]]
+[[Category: Yml079wp]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:54:57 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:48:26 2008''