5uci: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5uci is ON HOLD  until Paper Publication
==Hsp90b N-terminal domain with inhibitors==
 
<StructureSection load='5uci' size='340' side='right' caption='[[5uci]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
Authors: Peng, S., Balch, M., Matts, R., Deng, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5uci]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UCI FirstGlance]. <br>
Description: Hsp90b N-terminal domain with inhibitors
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=874:(2,4-Dihydroxy-3-(hydroxymethyl)-5-isopropylphenyl)(isoindolin-2-yl)methanone'>874</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uch|5uch]], [[5ucj|5ucj]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uci OCA], [http://pdbe.org/5uci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uci RCSB], [http://www.ebi.ac.uk/pdbsum/5uci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uci ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Balch, M]]
[[Category: Deng, J]]
[[Category: Deng, J]]
[[Category: Matts, R]]
[[Category: Peng, S]]
[[Category: Peng, S]]
[[Category: Matts, R]]
[[Category: Chaperone-inhibitor complex]]
[[Category: Balch, M]]
[[Category: Hsp90 inhibitor]]

Revision as of 08:45, 3 January 2018

Hsp90b N-terminal domain with inhibitorsHsp90b N-terminal domain with inhibitors

Structural highlights

5uci is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.[1] [2]

References

  1. ↑ Chadli A, Graham JD, Abel MG, Jackson TA, Gordon DF, Wood WM, Felts SJ, Horwitz KB, Toft D. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Mol Cell Biol. 2006 Mar;26(5):1722-30. PMID:16478993 doi:http://dx.doi.org/26/5/1722
  2. ↑ Retzlaff M, Stahl M, Eberl HC, Lagleder S, Beck J, Kessler H, Buchner J. Hsp90 is regulated by a switch point in the C-terminal domain. EMBO Rep. 2009 Oct;10(10):1147-53. Epub 2009 Aug 21. PMID:19696785 doi:http://dx.doi.org/embor2009153

5uci, resolution 2.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5uci&oldid=2839391"