5uc4: Difference between revisions

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-'''Unreleased structure'''
-The entry 5uc4 is ON HOLD  until Paper Publication
+==Hsp90b N-terminal domain with inhibitors==
+<StructureSection load='5uc4' size='340' side='right' caption='[[5uc4]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5uc4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UC4 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=83S:5-Hydroxy-4-(isoindoline-2-carbonyl)-2-isopropylbenzaldehyde'>83S</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uc4 OCA], [http://pdbe.org/5uc4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uc4 RCSB], [http://www.ebi.ac.uk/pdbsum/5uc4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uc4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Balch, M]]
+[[Category: Deng, J]]
+[[Category: Matts, R]]
+[[Category: Peng, S]]
+[[Category: Chaperone-inhibitor complex]]
+[[Category: Hsp90]]
+[[Category: Inhibitor]]