5owb: Difference between revisions

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'''Unreleased structure'''


The entry 5owb is ON HOLD
==Crystal structure of the human BRPF1 bromodomain in complex with DSPBP1004==
 
<StructureSection load='5owb' size='340' side='right' caption='[[5owb]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
Authors: Zhu, J., Spiliotopoulos, D., Caflisch, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5owb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OWB FirstGlance]. <br>
Description: Crystal structure of the human BRPF1 bromodomain in complex with DSPBP1004
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AYW:4-methyl-6-oxidanyl-1-benzofuran-3-one'>AYW</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5owb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5owb OCA], [http://pdbe.org/5owb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5owb RCSB], [http://www.ebi.ac.uk/pdbsum/5owb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5owb ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caflisch, A]]
[[Category: Spiliotopoulos, D]]
[[Category: Spiliotopoulos, D]]
[[Category: Caflisch, A]]
[[Category: Zhu, J]]
[[Category: Zhu, J]]
[[Category: Dna binding protein]]
[[Category: Inhibitor]]
[[Category: Transcription]]

Revision as of 10:20, 18 July 2018

Crystal structure of the human BRPF1 bromodomain in complex with DSPBP1004Crystal structure of the human BRPF1 bromodomain in complex with DSPBP1004

Structural highlights

5owb is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.[1] [2]

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Ullah M, Pelletier N, Xiao L, Zhao SP, Wang K, Degerny C, Tahmasebi S, Cayrou C, Doyon Y, Goh SL, Champagne N, Cote J, Yang XJ. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol. 2008 Nov;28(22):6828-43. doi: 10.1128/MCB.01297-08. Epub 2008 Sep , 15. PMID:18794358 doi:10.1128/MCB.01297-08

5owb, resolution 1.65Å

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