1w0y: Difference between revisions

Revision as of 13:00, 3 May 2008

TF7A_3771 COMPLEX

OverviewOverview

Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.

About this StructureAbout this Structure

1W0Y is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864 Page seeded by OCA on Sat May 3 13:00:35 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1w0y.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1w0y |SIZE=350|CAPTION= <scene name='initialview01'>1w0y</scene>, resolution 2.50&Aring;
+The line below this paragraph, containing "STRUCTURE_1w0y", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Cac+Binding+Site+For+Chain+H'>AC1</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=771:4-(4-BENZYLOXY-2-METHANESULFONYLAMINO-5-METHOXY-BENZYLAMINO)-BENZAMIDINE'>771</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1w0y|  PDB=1w0y  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0y OCA], [http://www.ebi.ac.uk/pdbsum/1w0y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w0y RCSB]</span>
-}}
 '''TF7A_3771 COMPLEX'''
@@ Line 35: / Line 32: @@
 [[Category: Wallbaum, S.]]
 [[Category: Weber, L.]]
-[[Category: blood coagulation]]
+[[Category: Blood coagulation]]
-[[Category: calcium-binding]]
+[[Category: Calcium-binding]]
-[[Category: co-factor]]
+[[Category: Co-factor]]
-[[Category: coagulation]]
+[[Category: Coagulation]]
-[[Category: enzyme complex]]
+[[Category: Enzyme complex]]
-[[Category: gamma-carboxyglutamic acid]]
+[[Category: Gamma-carboxyglutamic acid]]
-[[Category: glycoprotein]]
+[[Category: Glycoprotein]]
-[[Category: hydrolase]]
+[[Category: Hydrolase]]
-[[Category: plasma]]
+[[Category: Plasma]]
-[[Category: serine protease]]
+[[Category: Serine protease]]
-[[Category: vitamin k]]
+[[Category: Vitamin k]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:00:35 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:29:37 2008''