1hbk: Difference between revisions
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[[Image:1hbk.gif|left|200px]]<br /> | [[Image:1hbk.gif|left|200px]]<br /><applet load="1hbk" size="450" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1hbk" size="450" color="white" frame="true" align="right" spinBox="true" | |||
caption="1hbk, resolution 2.00Å" /> | caption="1hbk, resolution 2.00Å" /> | ||
'''ACYL-COA BINDING PROTEIN FROM PLASMODIUM FALCIPARUM'''<br /> | '''ACYL-COA BINDING PROTEIN FROM PLASMODIUM FALCIPARUM'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1HBK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] with NI, COA and MYR as [http://en.wikipedia.org/wiki/ligands ligands]. | 1HBK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] with NI, COA and MYR as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=COA:Coa Binding Site For Chain A'>COA</scene>, <scene name='pdbsite=MYR:Myr Binding Site For Chain A'>MYR</scene>, <scene name='pdbsite=NI1:Ni Binding Site For Residue A1091'>NI1</scene> and <scene name='pdbsite=NI2:Ni Binding Site For Residue A1092'>NI2</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HBK OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: fatty acid metabolism]] | [[Category: fatty acid metabolism]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 16:13:29 2007'' | ||
Revision as of 17:03, 18 December 2007
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ACYL-COA BINDING PROTEIN FROM PLASMODIUM FALCIPARUM
OverviewOverview
Acyl-CoA binding protein (ACBP) maintains a pool of fatty acyl-CoA, molecules in the cell and plays a role in fatty acid metabolism. The, biochemical properties of Plasmodium falciparum ACBP are described, together with the 2.0 A resolution crystal structures of a P. falciparum, ACBP-acyl-CoA complex and of bovine ACBP in two crystal forms. Overall, the bovine ACBP crystal structures are similar to the NMR structures, published previously; however, the bovine and parasite ACBP structures are, less similar. The parasite ACBP is shown to have a different, ligand-binding pocket, leading to an acyl-CoA binding specificity, different from that of bovine ACBP. Several non-conservative differences, in residues that interact with the ligand were identified between the, mammalian and parasite ACBPs. These, together with measured, binding-specificity differences, suggest that there is a potential for the, design of molecules that might selectively block the acyl-CoA binding, site.
About this StructureAbout this Structure
1HBK is a Protein complex structure of sequences from Plasmodium falciparum with NI, COA and MYR as ligands. Known structural/functional Sites: , , and . Full crystallographic information is available from OCA.
ReferenceReference
Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein., van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA, J Mol Biol. 2001 May 25;309(1):181-92. PMID:11491287
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