User:Dotan Shaniv/Sandbox 1: Difference between revisions

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</table>

== Function ==

[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors are [[G_protein-coupled_receptor|G Protein-Coupled Receptors]], i.e. they mediate the catecholamine-induced activation of [[adenylate cyclase]] through the action of [[GTP-binding_protein|G proteins]]. The beta-2-adrenergic receptor is widely distributed in the respiratory tract and is found on many types of cells there, such as smooth muscle cells, epithelial and endothelial cells, mast cells and more<ref>PMID: 16387578</ref>. binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors are [[G_protein-coupled_receptor|G Protein-Coupled Receptors]], i.e. they mediate the catecholamine-induced activation of [[adenylate cyclase]] through the action of [[GTP-binding_protein|G proteins]]. The beta-2-adrenergic receptor is widely distributed in the respiratory tract and is found on many types of cells there, such as smooth muscle cells, epithelial and endothelial cells, mast cells and more<ref>PMID: 16387578</ref>. The natural ligands for adrenoceptors are epinephrine\norepinephrine (it may be worth noting that the beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine). When these ligands bind to adrenoceptors they activate them (i.e. they are their natural agonists), which in the case of the beta-2-adrenergic receptor translates to the sympathetic effect in the respiratory tract, namely, bronchodilation. This is the reason that the beta-2-adrenergic receptor is the main target in [http://en.wikipedia.org/wiki/Asthma Asthma] treatment - drugs that function as beta-2 agonists help to activate these receptors and allow patients to deal with acute or chronic asthma symptoms.

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors are [[G_protein-coupled_receptor|G Protein-Coupled Receptors]], i.e. they mediate the catecholamine-induced activation of [[adenylate cyclase]] through the action of [[GTP-binding_protein|G proteins]]. The beta-2-adrenergic receptor is widely distributed in the respiratory tract and is found on many types of cells there, such as smooth muscle cells, epithelial and endothelial cells, mast cells and more<ref>PMID: 16387578</ref>. binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
+[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors are [[G_protein-coupled_receptor|G Protein-Coupled Receptors]], i.e. they mediate the catecholamine-induced activation of [[adenylate cyclase]] through the action of [[GTP-binding_protein|G proteins]]. The beta-2-adrenergic receptor is widely distributed in the respiratory tract and is found on many types of cells there, such as smooth muscle cells, epithelial and endothelial cells, mast cells and more<ref>PMID: 16387578</ref>. The natural ligands for adrenoceptors are epinephrine\norepinephrine (it may be worth noting that the beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine). When these ligands bind to adrenoceptors they activate them (i.e. they are their natural agonists), which in the case of the beta-2-adrenergic receptor translates to the sympathetic effect in the respiratory tract, namely, bronchodilation. This is the reason that the beta-2-adrenergic receptor is the main target in [http://en.wikipedia.org/wiki/Asthma Asthma] treatment - drugs that function as beta-2 agonists help to activate these receptors and allow patients to deal with acute or chronic asthma symptoms.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

User:Dotan Shaniv/Sandbox 1: Difference between revisions

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